The antibiotic-free feed has been the worldwide trend. Although antibiotic growth promoter could effectively inhibit pathogenic bacteria, decrease diarrhea rate, and improve growth, it has severe side effects with the emergence of “superbugs” (antibiotic-resistant bacteria). Therefore, it has been the common goal for the agricultural industry to establish a non-antibiotic scheme for disease resistance, diarrhea prevention, and growth promotion. The pioneers from Europe have selected acidifiers, probiotics, and enzymes as the most effective alternatives to antibiotics in the last 30 years. Each alternative performs different functions: acidifiers are used to improve nutrients digestibility, inhibit harmful bacteria, and reduce intestinal inflammation; probiotics are used to regulate gut microbiota and strengthen immunity; enzymes are used to improve nutrients digestibility, thus improving the growth of animals. Based on the trials data accumulated for many years, Sunhy has developed an upgraded solution to completely replace antibiotics by the combination of organic acids, probiotics, and enzymes such as glucose oxidase, which have been verified by customers in different feed formulations in different countries.